Endocrine Abstracts

Background: Investigating the origin of ACTH determine disparate treatment and prognosis in ACTH-dependent Cushing’s Syndrome. We want to detect the value of combination of HDDST and DDAVP stimulation test for identifying Cushing’s disease (CD) and Ectopic ACTH-dependent Cushing’s Syndrome (EAS).Methods: We retrospectively recorded 102 ACTH-dependent Cushing’s Syndrome (87 CD and 15 EAS) in West China Hospital from January 1, 2010...

Objective: To examine the relationship between C-peptide levels and endogenous insulin secretion and to understand the effects of elevated C-peptide after dosing on evaluating study insulin and its analogs’ PK/PD values in euglycemic clamps.Method: The study included 33 healthy male volunteers who underwent an 8-h euglycemic clamp with a subcutaneous injection of insulin aspart (0.2 U/kg). Blood glucose (BG), C-peptide, human insulin, and insu...